Improve mental performance
Boost learning and memory
Normalize Stress Levels
Increase endurance
Turn back brain-aging
Improve mental performance

Flavay Plus® improves cognitive performance, strengthens memory and decreases stress in clinical trials.

Researchers found Flavay® worked as well as commonly prescribed medications, including Ritalin, on children and adults diagnosed with attention disorders. Many of the subjects also had other positive effects. (15)

A study of 30 children and adults diagnosed with ADD found Flavay® worked just as well as the commonly prescribed stimulant medications, including Ritalin. The subjects were given a battery of computerized and behavior tests to judge their attention, concentration, and other important ADD factors. Tests were conducted three times in three ways: off their usual stimulant meds, back on the meds, and then with Flavay® alone. Off their medications, their ADD symptoms deteriorated. On their medications, they were much improved. With Flavay®, their scores and behavior were just as improved as when they took stimulant drugs. Many of the subjects also had other positive effects. (15)

By modulating nitric oxide in brain cells, Flavay® supports regulation of the enzymes which control the crucial neurotransmitters dopamine and norepinephrine, chemicals that carry messages among brain cells and are involved in excitatory responses. (14,103,53,202-204,265,274)
Chart shows taking Flavay Plus results in improvements in short-term memory after two months: Significant improvement in short-term memory in children, ages 4-14

A placebo-controlled study of 120 students shows Flavay Plus® for 40 days may improve directed memory, associative learning, free memory, recognition and visual memory. (338)

A double-blind, placebo controlled clinical trial on young healthy university students subjected to standard acute stress tests composed of mental arithmetic under time pressure. Stress was monitored by heart rate. Results show taking Flavay Plus® “scored significantly better, were more clear-headed, confident and composed.” (125)

A randomized, double-blind, placebo-controlled study on healthy young golfers with handicaps of 15–40. Results show taking Flavay Plus® improved perceived stress levels and performance (significantly improved the number of good ball flights during tee-off which might result in improved golf scores). (215)

Boost learning and memory

Flavay Plus® shows significant improvement in focus and short-term memory in clinical trials.

Chart shows taking Flavay Plus results in significant improvements in short-term memory after two months: Significant improvement in short-term memory in children, ages 4-14

A randomized, double-blind, placebo-controlled study performed on 36 children (ages 4 to 14) who had not previously received any drug treatment related to ADHD. Main outcome measures included: (i) ADHD symptoms based on DSM-IV-TR; (ii) short-term auditory memory and working memory using the Digit Span Test of the Wechsler Intelligence Scale for Children; and (iii) mental performance to visual stimuli (GO/NO GO task). Results show taking Flavay Plus® “significantly improved ADHD symptoms and short-term auditory memory in children.” No adverse events and no side effects were found. (217)

Another study of 15 children (ages 6–12) with ADHD shows taking Flavay Plus® daily for 2 months significantly improved ADHD symptoms. Significant improvement was observed both in inattention and in hyperactivity and impulsiveness, and visual perception was also significantly improved. No adverse events and no side effects were found. (218)

Normalize Stress Levels

Flavay Plus® boosts the weak stress response in the elderly person and calms down exaggerated stress in the healthy young person.

Chart shows Flavay Plus significantly inhibits ACTH and cortisol (stress-induced and exercise-induced hormones) in response to exercise.

A double-blind, placebo-controlled study of healthy males (ages 24-42) shows Flavay Plus® significantly suppresses stress hormone levels in response to exercise. (Mental and physical stress result in the same physiological responses.) (134)

Another double-blind, placebo-controlled, crossover study was conducted on healthy male athletes. Blood samples were taken at (1) rest, (2) after a 15-minute moderately intense exercise on a cycle ergometer, and (3) during a 65-minute passive recovery period. After ten sessions in ten days, results showed that cortisol levels were significantly reduced in the Flavay Plus® group, testosterone was significantly increased and the ratio between the two hormones was significantly elevated in the Flavay Plus® group—indicating a reduction in stress and improved recovery. (216)

Both physical and mental stressful conditions cause stress hormones to be released into circulation, even in the young and healthy. Flavay Plus® for athletes prior to starting exercise produced an impressive degree of down-regulation of the stress hormones. Flavay Plus® may have the capacity to “normalize” the stress-induced activation of the hypothalamic-pituitary-adrenal axis. A double-blind, placebo-controlled study conducted in Italy shows Flavay Plus® may lower stress-induced hormone (cortisol) production by 30 percent. (117)

Increase endurance

Flavay Plus® increases endurance and time to exhaustion in clinical trials.

Chart shows Flavay Plus significantly increases endurance. Graph compares placebo baseline, placebo endpoint, Flavay Plus baseline, Flavay Plus endpoint and shows 30% more time to exhaustion with Flavay Plus.

A double-blind, placebo controlled study with 14 healthy and trained male athletes underwent cycling exercise prior to and following the supplementation period. Endurance was measured using a cycle ergometer at 85% VO2 max. After ten days, the group taking Flavay Plus® experienced about 30% more time before exhaustion, while the placebo group experienced no change. (258)

Turn back brain-aging

Clinical trial shows taking Flavay Plus® (4 per day) for 12 weeks may result in reversal of brain-aging by nearly 14 years.

Chart shows taking 4 Flavay Plus per day for 12 weeks results in reversal of brain-aging by nearly 14 years. Chart shows the following test results: 13.9 years of improvement for remembering names after introduction; 11.6 years of improvement for learning and remembering written information; 7.4 years of improvement for recognizing a previously seen person; and 3.9 years of improvement in dialing a ten-digit phone number from memory. Chart shows taking 4 Flavay Plus per day for 0, 6 and 12 weeks results in significant improvements in elderly subjects in the following tests: memory recognition, memory recall, executive functions, and mental flexibility.

(Above:) Data from objective neuro-psychological testing shows taking Flavay Plus® (4 per day) for 12 weeks may result in reversal of brain-aging of nearly 14 years. Improvements were found in learning and remembering written information, remembering names and recognizing people, and memory of numbers. (126,168)

A study of 75 seniors with age-related memory impairment found taking (4) Flavay Plus® per day for 12 weeks led to improved performance tests related to learning and memory tasks of daily life. (166)

A study of 33 persons with dementia shows equally promising results. This eight-week study shows (4) Flavay Plus® per day can significantly improve dementia. (123)

Double-Blind, Placebo-Controlled, Crossover Studies = Flavay Plus® (4 per day)

Methods Population Duration Conclusions
Crichton and Peri geriatric rating scales 35 hospitalized senile demented patients, ages 65-91 6 weeks randomized, placebo-controlled, double-blinded and three weeks follow-up Statistically significant behavioral improvement in both scales (219)
Plutchik Geriatric Rating Scale 87 subjects with moderate cognitive deterioration, ages 55-80 8 weeks randomized, placebo-controlled, double-blinded and four weeks follow-up Beneficial for cognitive effects (220)
Brain physiology (EEG) 39 elderly subjects with arteriosclerotic encephalopathy, ages 55+ 12 weeks placebo-controlled, double-blinded and four weeks follow-up Improved discrimination (221)
The Set Test (Isaacs & Akhtar) and parameters like daily living, information, personal memory, non-personal memory 142 subjects with Alzheimer’s disease, ages 40-80 12 weeks placebo-controlled, double-blinded with 12- and 24-weeks follow-up Significant improvement (p<0.05) (222)
Learning and memory tasks 51 subjects with Alzheimer’s disease, ages 55-80 12 weeks placebo-controlled, double-blinded Improvement in cognitive impairment (223)
Plutchik Geriatric Rating Scale and Buschke Selective Reminding Test 425 geriatric patients with moderate to severe cognitive decline, ages 65-93 24 weeks placebo-controlled, double-blinded Statistically significant improvements (114)

Methods of Action

Flavay: International and U.S. Patents and Clinically Proven

Flavay® is patented as a scavenger of the free radicals that play a major role in the initiation, duration and breakdown of inflammation and in ischaemia (reduced blood flow).

“[A] method for preventing and fighting the harmful biological effects of free radicals in the organism of warm blooded animals and more especially human beings, namely cerebral involution, hypoxia following atherosclerosis, cardiac or cerebral infarction, tumour promotion, inflammation, ischaemia, alterations of the synovial liquid, collagen degradation, among others.”
—U.S. Patent No. 4,698,360 (1987).

Improved Blood Flow

Decreased blood flow to the brain plays a major role in brain disorders. Neurons become more active when blood flow increases. (14,231,339)
Clinical trials show Flavay® improves circulation and strength and tone of veins, arteries, capillaries, lymph vessels, lymph nodes, and lymphoid tissues. (44-48,104)

Neuroprotective Effects
Against Oxidative Stress and Inflammation

Oxidative stress-mediated inflammation is attributed to neurodegenerative diseases including Alzheimer's and Parkinson's diseases. Brain aging is also associated with elevated levels of neuro-inflammation which is intimately linked to oxidation. (379-384)
Flavay® decreases inflammation by preventing free radically-induced release and synthesis of compounds that promote inflammation, including histamine, serine proteases, prostaglandins and leukotrienes. (18,25,61,74,81) Flavay® significantly increases serum total antioxidant activity in cells and stimulates antioxidant defense systems. (33,83,274,276,370)

Neurotransmitter Metabolism,
Nitric Oxide Metabolism and Histamine Activities

Nitric oxide and histamine are now recognized as very important signaling molecules for intercellular and intracellular communication throughout the body. (14,102,232-236,248,352,353,377)
Flavay® protects healthy histamine activity. Studies show Flavay® lowers inflammatory and allergic activity of histamine with as much as 86% inhibition of histidine decarboxylase. Researchers noted Flavay® has both anti-inflammatory and anti-allergy activity. (35,56,77-79,87,146)
All higher brain functions require a well-balanced release of nitric oxide in the brain. Nitric oxide also plays a major role in the function of the blood-brain barrier, as it consists mainly of microvascular endothelial cells which are regulated by nitric oxide. (202-204,374)
Flavay® reduces production of stress hormones and interference with neurotransmitters as it modulates nitric oxide in brain cells. Flavay® is shown to both stimulate normal synthesis and inhibit overproduction of nitric oxide. (14,103,53,202-204,265,274)
When nitric oxide is over-produced, a chain reaction begins which causes neurons to break down and destroy surrounding healthy cells. In Alzheimer’s, free radicals attack cell membranes of the hippocampus, the memory region. In Parkinson’s disease, the area of the brain to suffer the most damage is the “substantia nigra,” which produces dopamine, the neurotransmitter responsible for muscle movement and coordination. (14,232-236,240-242,380)
Flavay® protects against toxic overproduction of nitric oxide by blocking nitric oxide synthase. Research shows Flavay® prevents free-radical damage to macrophages, a type of white blood cell that generates nitric oxide to destroy bacteria, viruses, and host parasites. This is important because when macrophages over-produce nitric oxide the brain-immune connection is damaged—and that is the genesis of many neurological diseases. (14,202-204,261,271,301)
Acetylcholine decline is a hallmark of neurodegenerative disease and coincides with advancing age. (330)
Chart of young versus old shows supplementation with Flavay Plus restores a healthy supply of acetylcholine. Acetylcholine is a brain transmitter essential to memory, cognition, sleep and neuromuscular control.
(Above:) Flavay Plus® is shown to restore acetylcholine synthesis and release. Acetylcholine is a neurotransmitter essential to memory, cognition, sleep and neuromuscular control. (127)
Dopamine levels naturally fall by up to 10% every decade. Irrespective of age, decreases in brain dopamine activity are associated with a decline in motor function and impaired performance on tasks that involve frontal brain regions (problem-solving, personality and social interaction, and spatial orientation). (378)
Chart of young versus old shows supplementation with Flavay Plus restores healthy youthful levels of dopamine. Dopamine is a brain transmitter which regulates the sense of well-being, reward-behavior, mood and bodily coordination.
(Above:) Flavay Plus® is shown to restore supply and output of dopamine— essential to memory, attention and problem-solving. Dopamine is also associated to the sense of well-being, reward-behavior, mood and bodily coordination. (128-133,331,332)

Stress-Hormone Activities

The Journal of Autism and Developmental Disorders reported that children with ADHD experienced abnormal rhythms in the cortisol (stress-induced and exercise-induced hormone). (14,195)
Research demonstrates Flavay Plus® helps calm down exaggerated stress, shown to significantly suppress cortisol levels in response to exercise. (Mental and physical stress result in the same physiological responses.) (110,114,119,134,216)
Both physical and mental stressful conditions cause stress hormones to be released into circulation, even in the young and healthy. A double-blind, placebo-controlled study shows that Flavay Plus® may lower stress-induced hormone (cortisol) production by 30 percent. (117)

Conclusion

Flavay Plus® is effective for improving memory, mental focus, mood, cognitive performance, learning ability, and coping with stress.

Scores of published human studies, including double-blind clinical trials establish that Flavay Plus® can rejuvenate brain cell membranes and thereby

Change the way you grow older by protecting your brain for the many years ahead.

Customer Reviews

I know taking vitamins is good for you but this is much more than that. Because of taking Flavay and Flavay Plus I experience substantial improvement in mental sharpness, acuity and in the ability to react quickly and stay on top of situations while auto racing. —dentist*

My husband swears by Flavay Plus. He's a truck driver and Flavay Plus keeps him calm and at the same time his energy lasts long. He wouldn't do without it. —Ms. C.K.*

I just wanted to write and say WOW... I was so skeptical of your product at first and really had a negative attitude when I started taking it. I am a 40 yr old female with anxiety, mild ADHD and a host of arthritis and inflammation issues. It was a struggle for me to get out of bed everyday and focus on what needed to be done. I had no focus, no attention span, no energy, and no desire to do anything. About a week into taking Flavay and Flavay Plus, I started noticing that I could think a little clearer. My rheumatoid arthritis flare-ups weren't so bad, though I still have them. feeling better, and having more energy. I never thought I would feel like my old self again. I don't know exactly how you do it,...but this stuff works! I am telling all of my friends to try it because you've given me my old life back! Thank you! —Ms. L.A.*

I have used Flavay and Flavay Plus for almost a month and I really have not felt this healthy for so long. Fantastic energy and better overall. I have ms (small letters intentional, I hate it) and am feeling better even at work, people have commented my skin is better than it has ever been. I have great energy, it is incredible. —Mr. G.S.*

After one month of taking Flavay and Flavay Plus, I feel really good. I feel younger, like I used to feel 5 years ago, so that I want to start a business, and other things like that. My wife says I even look different. —Mr. R.K.*

I take 4 capsules of Flavay Plus every morning and I can keep going all day, and I stay focused too. I'm going to get both of my sons on Flavay Plus. —Mr. T.C.*

I want to thank you for Flavay Plus, it's just wonderful. My anxiety, panic and stress levels plummeted and my skin became clear and radiant. —Ms. J.C.*

I have used Flavay and Flavay Plus for almost a month and I really have not felt this healthy for so long. Fantastic energy and better overall. I have ms (small letters intentional, I hate it) and am feeling better even at work, people have commented my skin is better than it has ever been. I have great energy, it is incredible. —Mr. G.S.*

I began giving my daughter Flavay Plus for ADD and then I decided to add Flavay for my daughter's allergies. I want to tell you, the Flavay works like a charm for my daughter’s allergies. She is 6 years old, and when we ran out of capsules this week she told me, “You've got to get more Flavay!” —Ms. S.S.*

My son was born with a cleft palate and learning disabilities. I am no believer in nutrients but Flavay Plus is helping my son to calm down and stay on task. I recently ran out and my son told me that ‘not taking Flavay Plus makes me act crazy,’ so I know he can tell the difference. —Ms. E.W.*

I'm 26 and have a severe case of ADHD, and just recently started taking Flavay Plus. From the first week I was taking three to four pills per day, and feeling the results quite rapidly... I'm thrilled with the results I'm getting with Flavay Plus. —Ms. T.A.*

Flavay Plus has worked amazingly for my son in school. I don't have the same issue with ADHD like he does but I started taking it just because I saw what it did for him and it's helped so much with making me sharper and more clear minded. —Ms. A.M.*

I have had my son on Flavay Plus now for a couple months and his test scores have dramatically improved in school!!! —Ms. M.H.*

It's (Flavay) working! My grandson is doing so much better in school. No more bad text messages from his teacher. I am so grateful. I'm so happy. —Ms. M.P.*

After two weeks my mom (85, with dementia) is telling me she feels good because she is remembering better. I’m very upbeat over this. Flavay Plus is doing just what you thought it would for my mom. —Ms. X.M.*

I ordered Flavay Plus for my son because he just started a job. He said it helps his concentration and really missed your product. —Mr. F.C.*

My sister has been using Flavay Plus and she tried to get me to order it but I resisted. Now my sister is doing better about remembering and focusing while I'm still suffering, so I’ve got to get some for myself. —Ms. Mary C.*

Flavay is terrific. I've had concentration problems, well, for 60 years, all my life. I couldn't have direct eye contact with people when talking with them because I couldn't concentrate. I told jokes but couldn't make people laugh because I couldn't keep my concentration. Now I can look people in the eye. Now I can make people laugh! I don't know how it works but it works and it is terrific. —Mr. Wayne M.*

I've got to have my Flavay. Keeps me going. Keeps me young. 4 Flavay every day. —Mr. C.S.*

My 13-year-old son started taking Flavay for ADD. He came home from school saying, ‘Mom! I felt so smart! I answered all of the questions!’ The teacher backed him up, saying he got every answer correct. So I will keep giving him Flavay. —Ms. Tammy A.*

Flavay works well with my son (6 years-old, with Autism). He's doing work at the proper level, anger issues are gone. —Ms. O.F.*

Thank you so much for all your help. Thank you for also improving my son's lifestyle (taking Flavay). —Ms. R.D.*

My grandson asked to start taking Flavay again. He is 14 years old and has ADD and anxiety and pain going down his arms and so Flavay must have been helping him because he is asking for it. (Follow-up:) Flavay is working! My grandson is doing so much better in school. No more bad text messages from his teacher. I am so grateful. I'm so happy. —Ms. M.P.*

I have found Flavay to be a wonderful product. I buy it for my mum's eyes, but we also notice it improves her cognitive function. —Ms. N.S.*

Your Flavay Plus is wonderful! I'm a nurse and I don't dare tell the doctors what my son is taking, you know they don't like supplements. This product is amazing. I put it in my son's food, he doesn't even know he is taking it. Thanks again for a wonderful product. —Ms. R. Lee*

* Results vary by person and are not guaranteed. NOTE: We do not compensate for our endorsements and testimonials. We do not consider paid testimonials to be nearly as valuable as comments from customers who were not compensated and yet liked the products so much they gave their testimonials anyway.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.