Not only does inflammation cause pain and suffering, but over time it causes tissue destruction and a wide variety of autoimmune diseases. We now understand the correlation between continued active inflammation and arthritis, diabetes, retinopathies, heart disease and Alzheimer’s. (14,379-384,407,456)
Inflammation is the immune system's primary reaction to destroy invaders by breaking down the genetic material of bacteria, toxins, and viruses. Inflammation continues until the invaders are eliminated and tissue repair is completed. However, continued active (chronic) inflammation overwhelms the body's cells with oxidative stress and thereby destroys the cell's defense antioxidant systems. (14,456)
How exciting, then, to discover a safe and effective way to fight back against inflammation. Clinically proven to significantly strengthen the antioxidant defense systems, improve intracellular serum total antioxidant activity and reduce inflammatory markers, Flavay® has been sold worldwide for reducing inflammation and edema (swelling) and extensively tested in humans for 70 years.
Important anti-inflammatory mechanisms of Flavay® are the inhibition of pro-inflammatory mediators including phospholipase A2, cyclooxygenase (COX-1 and COX-2), and lipoxygenase thereby reducing destructive ratios and concentrations of prostanoids, leukotrienes and thromboxanes. (Most importantly, this protection comes without the side effects common to NSAIDs.) (53,185,230,265,274,292,296,302)
Oxidative stress produces an increase in enzymes such as cyclooxygenase (COX) and lipoxygenase (LOX) which are implicated in the release of interleukins and chemokines, and it has been shown that Flavay® inhibits these pro-inflammatory enzymes. (391,185,230,387,388)
Scientific and clinical research establishes that Flavay® strengthens collagen in vascular walls and capillaries by making the vessels stronger and more elastic. Flavay® is shown to strengthen and rebuild the body’s natural collagen proteins and has the remarkable ability to reactivate collagen and elastin. Flavay® is also a strong antioxidant which protects collagen, elastin and hyaluronic acid from over-crosslinking and destructive inflammation-produced enzymes. (18,25,61,74,81)
Flavay®’s ability to reactivate damaged collagen and elastin is important for all the organs. Collagen is required for normal functioning of the joints, healthy cartilage and bones, smooth gliding surfaces, synovial fluid, normal joint spaces and normal soft tissues surrounding the joints. Collagen is the building block of connective tissue, veins, arteries, ligaments and tendons—and every tissue and every organ.
A double-blind, randomized, placebo-controlled study of 63 women undergoing treatment for lymph-edema resulting from breast cancer surgery found taking Flavay® (600 mg daily for six months) was superior to placebo in improving pain, skin tension, and arm and shoulder movements. (82)
In a double-blind, controlled trial of 32 subjects who had undergone facial cosmetic surgery, those given Flavay® for ten days had significantly less swelling than the placebo-treated group. (73)
In a randomized, controlled trial of 50 soccer players in France who had sustained sports injuries, those treated with Flavay® had significantly less swelling at the injured site over the next ten days than the placebo group. (88)
A similar study of soccer players in Australia also found the players who consumed Flavay® for ten days following their injuries experienced significantly less swelling than those who did not, and the swelling completely disappeared in some who were taking Flavay®. (80)
A review of three French double-blind clinical trials concluded that in subjects with chronic venous insufficiency, Flavay® significantly improved venous function in terms of swelling, pain, paresthesias (burning, numbness, tingling, or prickling) and nocturnal leg cramps. (42,230)
A much larger French study of 4,729 women taking hormone therapy reported that taking Flavay® (300 mg daily for three months) produced significant improvement in venous and lymphatic insufficiency. (59)
A multi-center study of 165 subjects with premenstrual symptoms, including breast tenderness, abdominal swelling, and pelvic pain found taking Flavay® resulted in 60% of subjects reporting improvement in, or cessation of, symptoms after initial treatment; when treatment duration doubled, subjects reporting improvement increased to 78%. (205)
A double-blind study of 50 subjects with chronic venous insufficiency found taking 150 mg Flavay® daily for one month had a more rapid and lasting effect on reducing peripheral edema (swelling) than 450 mg daily of Diosmin. (47)
A double-blind, placebo-controlled study of 92 subjects with chronic venous insufficiency demonstrated improved venous function at a daily dose of 300 mg of Flavay® for 28 days. 69% of those taking Flavay® reported 50% reduction in clinical parameter scores for pain, paresthesias (burning, numbness, tingling, or prickling), nocturnal cramps and edema (swelling). 75% of those taking Flavay® felt it was effective. (48)
Flavay® (100 mg per day) improved all cases of exudations (oozing fluids) on 147 subjects with retinopathy. (69)
An open study measured the effects of Flavay® on 26 subjects with retinopathy and capillary fragility, microaneurysms, exudates (oozing fluids) and hemorrhages. Capillary fragility (measured with Parrot's angiosterrometer) improved in 11 subjects, condition of the ocular fundus improved in 15 subjects, and overall improvement in 21 subjects was reported. (250)
A review of 26 clinical studies reveals Flavay® significantly improved vascular lesions, microaneurysms, and exudates (oozing fluids) associated with diabetic retinopathy. (71)
The effects of Flavay® (150 mg per day) were measured on 30 retinopathy subjects who suffered from microaneurysms, hemorrhages, exudations (oozing fluids) and neovascularization after capillary hypoxia. Retinal infectional lesions were stabilized in 80% of those taking Flavay®. (72)
A study of 11 persons with systemic lupus erythematosus, shows taking Flavay® (along with usual medications) reduces inflammation associated with lupus. Significant reductions in lymphocyte apoptosis, T-lymphocyte activation, reduced generation of reactive oxygen species (ROS) by neutrophils, lower erythrocyte sedimentation rates, and a decrease in the SLE disease activity index compared to the placebo group. The results show Flavay® can be useful as a second-line therapy to reduce inflammation in systemic lupus erythematosus. (422)
Flavay® prevented formation of gastric lesions by 80% in a series of seven in vivo studies conducted over a period of six months. Researchers found Flavay® directly restrained production of histamine from histadine and indirectly restrained release of histamine from mast cells. 146
In a similar gastric study, Flavay® lowered the production of histamine with as much as 86% by inhibition of the enzyme of histidine decarboxylase. (78)
Flavay® is shown to significantly suppress gastric mucosal injury, in a dose-dependent manner, in vivo. Myeloperoxidase (MPO) activities (marker of inflammation) are also significantly inhibited. Endogenous antioxidant, superoxide dismutase (SOD) activities are significantly stimulated by Flavay®. As to gastrointestinal hormones, the secretion of gastrin, somatostatin, and histamine are significantly inhibited, while prostaglandin E2 secretion are significantly stimulated. (425)
A study of three persons with chronic pancreatitis, characterized by epigastric pain with radiation to the back found a daily dose of 200-300 mg of Flavay® results in relief from pain. All subjects reported a significant reduction in pain severity and frequency of painful episodes, and two of three subjects reported a significant reduction in use of narcotic analgesics. All subjects reported their pain returned when they stopped treatment. (307)
Animal studies indicate taking Flavay® is beneficial in preventing hepatic and renal toxicity in cases of acetaminophen and other drug poisonings. This protection appears to be attributable to detoxification of cytotoxic free radicals or mediation of DNA repair.(309,310)
An animal study with myoglobinuric acute renal failure showed Flavay® administration reduces blood urea nitrogen and serum creatinine; histological improvement was also noted. (311)
A double-blind, randomized, placebo-controlled intervention study with 28 male smokers with 200 mg per day of Flavay®. At baseline, after 4 and 8 weeks researchers measured macro- and microvascular function and a cluster of systemic biomarkers for major pathological processes occurring in the vasculature: disturbances in lipid metabolism and cellular redox balance, and activation of inflammatory cells.
In the Flavay® group, serum total cholesterol and LDL decreased significantly by 5% and 7%, respectively in volunteers with elevated baseline levels. Additionally, after 8 weeks the ratio of glutathione to glutathione disulphide in erythrocytes rose from baseline by 22% the Flavay® group. Researchers observed that Flavay® supplementation exerts anti-inflammatory effects in blood towards ex vivo added bacterial endotoxin and significantly reduces expression of inflammatory genes in leukocytes and noted a "significant improvement of overall vascular health" in the Flavay® group. (454)
Flavay® stimulates normal synthesis and inhibit over-production of nitric oxide which stimulates collagen synthesis and subsequent healing at wound sites. (312,313)
In addition, the induction of vascular endothelial growth factor (VEGF) is a crucial step in the reepithelialization phase of skin repair. Flavay® appears to stimulate the expression of VEGF in cultured keratinocytes, suggesting how Flavay® supports wound healing. (314,315,316,317)
Flavay® works in multiple ways to lower inflammation: (1) by inhibiting release of compounds that promote inflammation, including histamine, serine proteases, prostaglandins and leukotrienes and (2) by improving vascular strength.
Study shows Flavay® significantly inhibits formation of pro-inflammatory cytokines, interleukin 1-beta, tumor necrosis factoralpha (TNF-alpha). (280)
Taking Flavay is shown to decrease levels of proinflammatory molecules C-reactive protein (CRP), interleukin-6 and tumor necrosis factoralpha (TNF-alpha). (435)
The anti-inflammatory effects of Flavay® are associated to inhibition of peroxide generation by macrophages. (272,278,279)
Several studies show Flavay® inhibits pro-inflammatory mediators phospholipase A2, cyclooxygenase (COX-1 and COX-2), and lipoxygenase thereby reducing destructive ratios and concentrations of prostanoids, leukotrienes and thromboxanes. (Most importantly, this protection comes without the side effects common to NSAIDs.)(53,265,274,292,296,302)
Flavay® is shown to inhibit lipoxygenase (LOX) and cyclooxygenase (COX). (185,230)
Flavay® enhanced IL-2 production by mitogen-stimulated splenocytes, decreased production of interleukin 6, and increased the cytotoxicity of natural killer cells. (318)
Two months of Flavay® significantly improved T- and B-cell function. (308)
Study shows Flavay® decreases levels of proinflammatory molecules C-reactive protein (CRP), interleukin-6 and tumor necrosis factoralpha (TNF-alpha). (435)
Flavay® significantly suppressed gastric mucosal injury, in a dose-dependent manner in vivo. Myeloperoxidase (MPO) activities (marker of inflammation) were also significantly inhibited. Endogenous antioxidant, superoxide dismutase (SOD) activities were significantly stimulated. As to gastrointestinal hormones, the secretion of gastrin, somatostatin, and histamine were significantly inhibited, while prostaglandin E2 secretion was significantly stimulated. (425)
The effectiveness of Flavay® in subjects with structural deformations (varicose veins) was tested against a placebo and Diosmin (a semisynthetic flavonoid). In both cases, Flavay® lessened functional problems during impaired venous back-flow. The researchers noted the importance of recognizing these functional problems before the varicose veins are visible. (46)
A double-blind study of 50 subjects with chronic venous insufficiency found taking 150 mg Flavay® daily for one month had a more rapid and lasting effect on reducing peripheral edema (swelling) than 450 mg daily of Diosmin. (47)
A double-blind, placebo-controlled study of 92 subjects with chronic venous insufficiency demonstrated improved venous function at a daily dose of 300 mg of Flavay® for 28 days. 69% of those taking Flavay® reported 50% reduction in clinical parameter scores for pain, paresthesias (burning, numbness, tingling, or prickling), nocturnal cramps and edema (swelling). 75% of those taking Flavay® felt it was effective, compared to 41% of the placebo group. (48)
A multi-center study of 165 subjects with premenstrual symptoms, including breast tenderness, abdominal swelling, and pelvic pain found taking Flavay® resulted in 60% of subjects reporting improvement in, or cessation of, symptoms after initial treatment; when treatment duration doubled, subjects reporting improvement increased to 78%. (205)
A double-blind, randomized, placebo-controlled study of 63 subjects undergoing treatment for lymph-edema resulting from breast cancer surgery found taking Flavay® (600 mg daily for six months) was superior to placebo in improving pain, skin tension, and arm and shoulder movements. (82)
A review of three French double-blind clinical trials concluded that in subjects with chronic venous insufficiency, Flavay® significantly improved venous function in terms of swelling, pain, paresthesias (burning, numbness, tingling, or prickling) and nocturnal leg cramps. (42,230)
A much larger French study of 4,729 women taking hormone therapy reported that taking Flavay® (300 mg daily for three months) produced significant improvement in venous and lymphatic insufficiency. (59)
In a double-blind, controlled trial of 32 subjects who had undergone facial cosmetic surgery, those given Flavay® for ten days had significantly less swelling than the placebo-treated group. (73)
In a randomized, controlled trial of 50 adults who had sustained sports injuries, those treated with Flavay® had significantly less swelling at the injured site over the next ten days than the placebo group. (88)
In a double-blind placebo controlled trial of 20 subjects with hepatic cirrhosis, supplementation with 300 mg daily of Flavay® significantly reduced capillary fragility. (45)
A French trial of 78 subjects with serious venous problems found very favorable results using Flavay®. 75 out of 78 (96%) subjects experienced improvement in circulation. (44)
Administration of Flavay® helped prevent capillary leaking in the brain, increasing the resistance of tight junctions in the arteriolar capillaries. (102)
A double-blind, randomized, placebo-controlled intervention study with 28 male smokers with 200 mg per day of Flavay®. At baseline, after 4 and 8 weeks researchers measured macro- and microvascular function and a cluster of systemic biomarkers for major pathological processes occurring in the vasculature: disturbances in lipid metabolism and cellular redox balance, and activation of inflammatory cells.
In the Flavay® group, serum total cholesterol and LDL decreased significantly by 5% and 7%, respectively in volunteers with elevated baseline levels. Additionally, after 8 weeks the ratio of glutathione to glutathione disulphide in erythrocytes rose from baseline by 22% the Flavay® group. Researchers observed that Flavay® supplementation exerts anti-inflammatory effects in blood towards ex vivo added bacterial endotoxin and significantly reduces expression of inflammatory genes in leukocytes and noted a "significant improvement of overall vascular health" in the Flavay® group. (454)
"[A] method for preventing and fighting the harmful biological effects of free radicals in the organism of warm blooded animals and more especially human beings, namely cerebral involution, hypoxia following atherosclerosis, cardiac or cerebral infarction, tumour promotion, inflammation, ischemia, alterations of the synovial liquid, collagen degradation, among others."
—U.S. Patent No. 4,698,360 (1987).
I just want to say that I love Flavay. When I stop taking it, the pain comes right back. —Mr. Mark H.*
My joints aren't hurting and my back feels better and I'm even able to work better. I'll tell you, I can feel Flavay! —Ms. C.V.*
My joints aren't hurting and my back feels better and I'm even able to work better. I'll tell you, I can feel Flavay! —Ms. C.V.*
I have lupus and taking Flavay enables me to move. I'm not able to do without it. I've been taking it for more than a decade and my skin looks younger, in fact people think I'm my kid's sister. —Ms. L.B.*
After about 6 to 9 weeks it made a profound difference. I’ve lost inches in swelling. I cannot say enough about Flavay! Over the years, I’ve stopped and started again and found for vascular and lymphatic edema, nothing is better than Flavay. —Ms. Marie D.*
I just want to say that I love Flavay. When I stop taking it, the pain comes right back. —Mr. Mark H.*
I feel flexibility, while tying my shoes, wow! The simple things work better. I feel a general sense of wellbeing with Flavay. —Mr. Peter M.*
I love your product called Flavay. I feel it does the job! —Mr. Robert B.*
I've got to have my Flavay. Keeps me going. Keeps me young. 4 Flavay every day. —Mr. C.S.*
I had a terrible accident where I fell 20 feet and injured my back and it was really bad. I went from a wheelchair to a cane and now I'm mowing the lawn. Flavay shrank the protruding disk so I could stand up straight again. I've referred many many people to your products, and it worked for them too. —Mr. Dave T.*
Flavay is a product I cannot stop taking. When I stopped taking it for a couple of weeks, my neuropathy and arthritis pain come raging back. So I started again on Flavay and the pain is almost completely gone. —Ms. Elsa D.*
I started taking Flavay for arthritis pain and I feel so much better! I'm so thrilled! —Ms. Susan S.*
After taking Flavay for just a week, my sister is doing things she couldn’t do before, such as bending over to pick things up off the floor. —Mr. Joe C.*
The puffiness in my legs is so much better. Oh my gosh this Flavay is great! —Ms. Joan G.*
Your Flavay really helps my husband's chronic pain syndrome and we're almost out! Please ship asap! —Ms. S.W.*
I was taking Flavay for pain and mobility. Now I take Flavay as much for the benefits to my skin as for joint pain. —Mr. H.S.*
Oh, I just love Flavay! I feel so much better! —Ms. Y.L.*
I can’t even tell you how much I appreciated finding your product Flavay and the incredible results and relief I have gotten from taking it... I skeptically ordered two bottles... And low and behold, it works. I read that I could take more than 2 that some people had to take 4 or 5 at a time, so I did, hoping and praying, and my prayers were answered. To say thank-you is an understatement, and I have been able to stop all other pain meds. I honestly was on a one way road to nowhere, now I am free again..a feeling I haven’t had in over 12 years. Thank-you!!!!!!!!!!!!!!! —Ms. Beth B.*
I am a nutritionist and I have referred two of my clients to take Flavay. Both of my clients have raved about the product. One of my clients has a problem with circulation and she said Flavay really works for her. —Mr. John H.*
I've got to have my Flavay. Keeps me going. Keeps me young. 4 Flavay every day. —Mr. C.S.*
My neighbor is so pleased with Flavay telling me how much better she feels. She has heart problems and taking 2 Flavay per day she has so much energy again and her color is better too. —Ms. C.V.*
I have tried everything else and your Flavay really helps my eyesight. I was having trouble seeing at night and now I don't have that problem anymore. I love Flavay. I also had a blown knee that they had wanted to do surgery on and now I don't have to. I love the Flavay, I really like it! —Ms. T.K.*
I start feeling pain in my joints after a few days of not taking Flavay. —Mr. Mark H.*
My daughter has rheumatoid arthritis in her knees and years ago Flavay had really helped her, so I want to order some more for her. —Ms. K.M.*
For several years I took Flavay for fibromyalgia and it really worked and I felt so much better. Now I need to start again. —Ms. C.H.*
I love your product called Flavay. I feel it does the job! —Mr. R.H.*
I have had joint pain in my hips for a couple years. I have been taking Flavay for about 30 days and I realized I don't have hip joint pain when laying down or sitting for long periods! I will continue to take it daily. —Ms. M.H.*
Thank you so much. I'm desperate!! 😊 Haven't taken them (Flavay and Flavay Plus) for a few months and can tell the difference! —Ms. S.A.*
Since I started taking Flavay I felt so good and I'm hoping to keep getting better. I started taking Flavay for my knee but since I started taking Flavay I've cut way back on asthma meds. The medication affects my brain badly. I want to control asthma instead of it controlling me. Flavay is a big help, I am so happy! —Ms. J.I.*
I began giving my daughter Flavay Plus for ADD and then I decided to add Flavay for my daughter's allergies. I want to tell you, the Flavay works like a charm for my daughter’s allergies. She is 6 years old, and when we ran out of capsules this week she told me, “You've got to get more Flavay!” —Ms. S.S.*
I just wanted to write and say WOW... I was so skeptical of your product at first and really had a negative attitude when I started taking it. I am a 40 yr old female with anxiety, mild ADHD and a host of arthritis and inflammation issues. It was a struggle for me to get out of bed everyday and focus on what needed to be done. I had no focus, no attention span, no energy, and no desire to do anything. About a week into taking Flavay and Flavay Plus, I started noticing that I could think a little clearer. My rheumatoid arthritis flare-ups weren't so bad, though I still have them. feeling better, and having more energy. I never thought I would feel like my old self again. I don't know exactly how you do it,...but this stuff works! I am telling all of my friends to try it because you've given me my old life back! Thank you! —Ms. L.A.*
I am not one to review products, but i can't deny some of the benefits i've experienced using both your biomor curcumin and flavay products. I've been taking both for a few months now, and the two major benefits i've noticed are 1) joint strength and mobility (for workouts) as i am lifting much heavier weights without injury 2) I am a paroxsymal Afib sufferer, and my episodes have gone from 2-3 per week down to zero (most weeks). This can't just be a coincidence. I think there is definitely something in your formulas that stop inflammation and get your body in balance and healing itself. —Mr. B.V.W.*
I damaged both knees in a motor cycle accident, (mostly pain and swelling ). I don't even think about my knees anymore , its been that long since they have caused me any pain. I have been taking Flavay for 3 Years, I had my right wrist diogonsed with carpal tunnel syndrome, ( hand and arm going to sleep) after having surgery on the left arm years ago, did not have the time for surgery( 3 week recovery) but since Flavay no more pain , the pin and needles are gone so I don't wake up in the middle of the night with my arms and hands bothering me. The amazing thing about this product it can take care of problems you just forgot you had, (or just learned to live with) . Now forget about them because the pain is gone. —Mr. B. Hall*
I really notice a difference when taking Flavay Plus, both in inflammation and in my stress levels. —Ms. W.L.*
I'm real happy about Flavay. It seems to have a positive effect on my lymph system. —Ms. R.M.*
I just love Flavay. If you ever need do a commercial, I’ll be happy to do it! —Ms. Linda M.*