Free radicals are molecules with unpaired electrons. Free radicals steal electrons from neighboring molecules, causing the affected molecule to also become unstable. This chain reaction leads to crosslinking of atomic structures—including proteins (including collagen), enzymes, DNA and RNA. (4,14,171,172,346-351)
Free radicals damage cells by attacking their various parts and altering cellular functions, causing mutations and cellular deaths, ultimately compromising tissue and organ functions —causing aging and diseases. (355,356)
The type of damage depends on which part of the cell is injured, as discussed below.
The antioxidants work as a network (synergistically) to fight free-radical damage and contribute to health and longevity.
As represented in the diagram above, Flavay® has greater scavenging capacity than vitamins C or E because Flavay® has more available electrons to donate. Inside the cell, Flavay® can trap eight free radicals where vitamin E can trap two and vitamin C can trap only one.
Vitamin C is found more effective in biosynthesis of collagen when in the presence of Flavay®. After vitamin C is recycled by Flavay®, vitamin C may trap another free radical and the cycle continues. This is why a number of research scientists have referred to Flavay® as the co-factor of vitamin C. (33,60,83,274)
"[A] method for preventing and fighting the harmful biological effects of free radicals in the organism of warm blooded animals and more especially human beings, namely cerebral involution, hypoxia following atherosclerosis, cardiac or cerebral infarction, tumour promotion, inflammation, ischemia, alterations of the synovial liquid, collagen degradation, among others."
—U.S. Patent No. 4,698,360 (1987).
Inflammation is caused by the overproduction of free radicals in a specific area of the body. The inflammatory response is a factor in arthritis, an umbrella term for more than 100 different diseases that produce either inflammation of the connective tissue (joints and tendons) or degeneration of the articular cartilage (a wearing down of the protective covering that cushions the end of bones, allowing bones to rub together without causing damage to the joints). (7,10)
Flavay® decreases inflammation by inhibiting release and synthesis of compounds that promote inflammation, including histamine, serine proteases, prostaglandins and leukotrienes. (18,25,61,74,81)
Flavay® lowers the inflammatory and allergic activity of histamine by protecting inert hyaluronidase enzymes from activation by oxidation. (Hyaluronidase activation also breaks down the hyaluronic acid in connective tissue.) Researchers noted Flavay® has both anti-inflammatory and anti-allergic activity. (3,35,56,78,146)
Various studies show Flavay® mediates nitric oxide activities and modulates the activity of the enzymes thromboxane A2, cyclooxygenase (COX-1 and COX-2), 5-lipoxygenase, and other inflammatory-causing compounds. Most importantly, this protection comes without the side effects common to NSAIDs. (53,230,265,274,292,296,302)
One of the clearest manifestations of free radical damage is over-crosslinking, which is where free radicals reactions cause proteins and/or DNA molecules to fuse together. Over-crosslinking damages proteins (including collagen), enzymes, DNA and RNA. (9)
Over-crosslinking makes collagen inflexible and non-functional and contributes to degeneration and accompanying diseases. (4,14,346-351)
Through synergistic action with vitamin C, Flavay® strengthens and rebuilds the body's natural collagen proteins and has the remarkable ability to reactivate collagen and elastin. Research demonstrates Flavay® binds to collagen fibers and realigns them to a more youthful, undamaged form. (Pure vitamin C is less effective in synthesis of collagen when the phytonutrients of Flavay® are missing. The same research also established that common bioflavonoids are completely inactive in this respect.) (18,19,23,60,266-268)
Over-crosslinking damages proteins (including collagen), enzymes, DNA and RNA. (4,14,171,172,346-351)
Free radicals are involved in the progression of heart disease in several different ways. Heart disease begins with the oxidation of LDL (low-density lipoproteins) cholesterol which leads to the formation of plaque in the arteries. If an artery becomes clogged with plaque, the result can be a heart attack (a sudden loss of blood and oxygen to the heart) or a stroke (loss of blood to the brain). Much of the damage that occurs in both heart attacks and strokes is caused by reperfusion injury, the burst of superoxide free radicals that surge in as blood flow resumes. (3,8,10)
Nitric oxide is essential for normal blood circulation as it controls the muscular tone of blood vessels and regulates circulation and blood flow. However, nitric oxide is a free radical and excessive amounts of nitric oxide can be deadly to the cardiovascular system and actually contribute to heart disease and strokes, and many other apparently different disorders (such as arthritis, asthma and Alzheimer's disease). So, in order to have good circulatory health, the body must maintain the right balance of nitric oxide—and that's the role of Flavay®. (10,239,265,292,296)
Flavay® is shown to improve vasodilation and mildly inhibit angiotensin-converting enzyme (ACE) by modulating nitric oxide metabolism in endothelial cells. (292,296)
Over 70 years of scientific and clinical research establishes that Flavay® strengthens collagen in vascular walls and capillaries and thereby makes the vessels stronger and more elastic. Flavay® is shown to increase capillary resistance, decrease capillary permeability, and increase rate of lymph flow. (47,48,60,82,205)
Free radicals are created when our bodies fight an infection. The immune system's cytokines go to work, sending messages to the brain that cause more white blood cells to mobilize. The more white blood cells the body activates, the more free radicals they produce, like pellets of poison, that go to work to destroy invaders by breaking down the genetic material of bacteria, toxins, and viruses. (14)
Unfortunately, free radicals can interfere with the biological components of our healthy cells in the same way they destroy invaders, literally dismantling the body's essential cellular proteins, fatty cell membranes and DNA. (7,14,346-351)
Some free radicals are beneficial when functioning properly. Nitric oxide and histamine are free radicals which act as neurotransmitters and immuno-transmitters when functioning correctly. In fact, nitric oxide and histamine are now recognized as very important signaling molecules for intercellular and intracellular communication throughout the body. (14,102,232-236,248,352,353,377)
All higher brain functions require a well-balanced release of nitric oxide in the brain. Nitric oxide also plays a major role in the function of the blood-brain barrier, as it consists mainly of microvascular endothelial cells which are regulated by nitric oxide. (202-204,374)
Protection of nitric oxide activity by Flavay® is important to brain functions because when nitric oxide is over-produced, a chain reaction begins which causes neurons to break down and destroy surrounding healthy cells. In Alzheimer's, free radicals attack cell membranes of the hippocampus, the memory region. In Parkinson's disease, the area of the brain to suffer the most damage is the "substantia nigra," which produces dopamine, the neurotransmitter responsible for muscle movement and coordination. (14,232-236,240-242)
See: Protect against neuronal dysfunction, neurotoxicity and neuro-inflammation
Due to the exposure to light and oxygen, the oxidative stress burden is higher in the eye than other tissues. Oxidative damage in responsible for macular degeneration, glaucoma, retinal degeneration and retinopathies, and cataracts. Our eyes (which are 80% collagen) rely on specialized aqueous (water) and lipid (fat) barriers for protection. But, our body's antioxidant mechanisms become progressively less effective as we age. (323-327)
The hallmark of optic neurodegenerative diseases (including retinopathy and glaucoma) is retinal ganglion cell-death. Studies show Flavay® protects oxidative stress-injured retinal ganglion cells by inhibiting apoptosis (cell-death). (257-259,299)
A number of epidemiologic studies have found that persons with age-related eye diseases had significantly lower levels of antioxidants, particularly vitamin C, than did persons who did not develop those eye conditions. Research shows Flavay® increases intracellular levels of vitamin C and E, and enhances the activity of vitamin A in human eyes. Also, Flavay® provides its own powerful antioxidant protection to the eyes and its tiny blood vessels. (1,81,63,64,71,202,260)
In clinical trials of persons with various types of retinal degenerations, including macular degeneration, diabetic retinopathy, retinitis pigmentosa, and hemorrhagic and hypertensive retinopathy, all persons taking Flavay® showed significant improvement. (69-72)
Other clinical studies show Flavay® significantly improves (both objectively and subjectively) light-dark vision impairment in persons who work at computer monitors and persons who drive at night. (63,64,65,71,262,263)
Flavay® is found to increase visual acuity in light-dark adaptations and recovery from glare by increasing the rate of rhodopsin regeneration (an important function of vitamin A). (63-65,71,262,263)
Flavay® is your best protection against "blue light" damage to your eyes. Licensed in France for for use in diabetic retinopathy, Flavay® should be part of the daily nutritional regimen of every aging person (most especially every diabetic person).
My joints aren't hurting and my back feels better and I'm even able to work better. I'll tell you, I can feel Flavay! —Ms. C.V.*
I have lupus and taking Flavay enables me to move. I'm not able to do without it. I've been taking it for more than a decade and my skin looks younger, in fact people think I'm my kid's sister. —Ms. L.B.*
After about 6 to 9 weeks it made a profound difference. I’ve lost inches in swelling. I cannot say enough about Flavay! Over the years, I’ve stopped and started again and found for vascular and lymphatic edema, nothing is better than Flavay. —Ms. Marie D.*
I just want to say that I love Flavay. When I stop taking it, the pain comes right back. —Mr. Mark H.*
I feel flexibility, while tying my shoes, wow! The simple things work better. I feel a general sense of wellbeing with Flavay. —Mr. Peter M.*
I love your product called Flavay. I feel it does the job! —Mr. Robert B.*
I've got to have my Flavay. Keeps me going. Keeps me young. 4 Flavay every day. —Mr. C.S.*
I had a terrible accident where I fell 20 feet and injured my back and it was really bad. I went from a wheelchair to a cane and now I'm mowing the lawn. Flavay shrank the protruding disk so I could stand up straight again. I've referred many many people to your products, and it worked for them too. —Mr. Dave T.*
Flavay is a product I cannot stop taking. When I stopped taking it for a couple of weeks, my neuropathy and arthritis pain come raging back. So I started again on Flavay and the pain is almost completely gone. —Ms. Elsa D.*
I started taking Flavay for arthritis pain and I feel so much better! I'm so thrilled! —Ms. Susan S.*
After taking Flavay for just a week, my sister is doing things she couldn’t do before, such as bending over to pick things up off the floor. —Mr. Joe C.*
The puffiness in my legs is so much better. Oh my gosh this Flavay is great! —Ms. Joan G.*
Your Flavay really helps my husband's chronic pain syndrome and we're almost out! Please ship asap! —Ms. S.W.*
I was taking Flavay for pain and mobility. Now I take Flavay as much for the benefits to my skin as for joint pain. —Mr. H.S.*
Oh, I just love Flavay! I feel so much better! —Ms. Y.L.*
I can’t even tell you how much I appreciated finding your product Flavay and the incredible results and relief I have gotten from taking it... I skeptically ordered two bottles... And low and behold, it works. I read that I could take more than 2 that some people had to take 4 or 5 at a time, so I did, hoping and praying, and my prayers were answered. To say thank-you is an understatement, and I have been able to stop all other pain meds. I honestly was on a one way road to nowhere, now I am free again..a feeling I haven’t had in over 12 years. Thank-you!!!!!!!!!!!!!!! —Ms. Beth B.*
I am a nutritionist and I have referred two of my clients to take Flavay. Both of my clients have raved about the product. One of my clients has a problem with circulation and she said Flavay really works for her. —Mr. John H.*
I've got to have my Flavay. Keeps me going. Keeps me young. 4 Flavay every day. —Mr. C.S.*
My neighbor is so pleased with Flavay telling me how much better she feels. She has heart problems and taking 2 Flavay per day she has so much energy again and her color is better too. —Ms. C.V.*
I have tried everything else and your Flavay really helps my eyesight. I was having trouble seeing at night and now I don't have that problem anymore. I love Flavay. I also had a blown knee that they had wanted to do surgery on and now I don't have to. I love the Flavay, I really like it! —Ms. T.K.*
I start feeling pain in my joints after a few days of not taking Flavay. —Mr. Mark H.*
My daughter has rheumatoid arthritis in her knees and years ago Flavay had really helped her, so I want to order some more for her. —Ms. K.M.*
For several years I took Flavay for fibromyalgia and it really worked and I felt so much better. Now I need to start again. —Ms. C.H.*
I love your product called Flavay. I feel it does the job! —Mr. R.H.*
I have had joint pain in my hips for a couple years. I have been taking Flavay for about 30 days and I realized I don't have hip joint pain when laying down or sitting for long periods! I will continue to take it daily. —Ms. M.H.*
Thank you so much. I'm desperate!! 😊 Haven't taken them (Flavay and Flavay Plus) for a few months and can tell the difference! —Ms. S.A.*
Since I started taking Flavay I felt so good and I'm hoping to keep getting better. I started taking Flavay for my knee but since I started taking Flavay I've cut way back on asthma meds. The medication affects my brain badly. I want to control asthma instead of it controlling me. Flavay is a big help, I am so happy! —Ms. J.I.*
I began giving my daughter Flavay Plus for ADD and then I decided to add Flavay for my daughter's allergies. I want to tell you, the Flavay works like a charm for my daughter’s allergies. She is 6 years old, and when we ran out of capsules this week she told me, “You've got to get more Flavay!” —Ms. S.S.*
I just wanted to write and say WOW... I was so skeptical of your product at first and really had a negative attitude when I started taking it. I am a 40 yr old female with anxiety, mild ADHD and a host of arthritis and inflammation issues. It was a struggle for me to get out of bed everyday and focus on what needed to be done. I had no focus, no attention span, no energy, and no desire to do anything. About a week into taking Flavay and Flavay Plus, I started noticing that I could think a little clearer. My rheumatoid arthritis flare-ups weren't so bad, though I still have them. feeling better, and having more energy. I never thought I would feel like my old self again. I don't know exactly how you do it,...but this stuff works! I am telling all of my friends to try it because you've given me my old life back! Thank you! —Ms. L.A.*
I am not one to review products, but i can't deny some of the benefits i've experienced using both your biomor curcumin and flavay products. I've been taking both for a few months now, and the two major benefits i've noticed are 1) joint strength and mobility (for workouts) as i am lifting much heavier weights without injury 2) I am a paroxsymal Afib sufferer, and my episodes have gone from 2-3 per week down to zero (most weeks). This can't just be a coincidence. I think there is definitely something in your formulas that stop inflammation and get your body in balance and healing itself. —Mr. B.V.W.*
I damaged both knees in a motor cycle accident, (mostly pain and swelling ). I don't even think about my knees anymore , its been that long since they have caused me any pain. I have been taking Flavay for 3 Years, I had my right wrist diogonsed with carpal tunnel syndrome, ( hand and arm going to sleep) after having surgery on the left arm years ago, did not have the time for surgery( 3 week recovery) but since Flavay no more pain , the pin and needles are gone so I don't wake up in the middle of the night with my arms and hands bothering me. The amazing thing about this product it can take care of problems you just forgot you had, (or just learned to live with) . Now forget about them because the pain is gone. —Mr. B. Hall*
I really notice a difference when taking Flavay Plus, both in inflammation and in my stress levels. —Ms. W.L.*
I'm real happy about Flavay. It seems to have a positive effect on my lymph system. —Ms. R.M.*
I just love Flavay. If you ever need do a commercial, I’ll be happy to do it! —Ms. Linda M.*