Red blood cells (erythrocytes) are extremely sensitive cells because, during inflammation, whether it is systemic or chronic, the blood is constantly exposed to circulating inflammatory mediators. Red blood cells have a highly specialized and organized membrane structure, which interacts and reacts to inflammatory molecule insults, and undergo programmed cell death, similar to apoptosis, known as eryptosis. (392)
Oxidative stress is an important accelerant and inducer of eryptosis (cellular death). Oxidative stress plays a key role in the progression of type 2 diabetes and affects the red blood cell membrane. Healthy cells have a large amount of glutathione (GPx) to buffer the damaging effects oxidative stress. (182,392)
As Flavay® strengthens connective tissue in vessel walls, studies show Flavay® improves the membrane protein structure of red blood cells so they can flex and change shape during circulation. Red blood cells must change shape extensively without rupturing for micro-circulation. Human clinical trials of persons with diabetes show Flavay® increases erythrocyte (red blood cell) deformability (flexibility) without increasing viscosity (resistance). (70,182,183)
A trial of 15 subjects with diabetes assessed the effect of Flavay® on blood flow rate and blood viscosity by measuring erythrocyte deformability by filterability index. After six weeks of taking Flavay® (400 mg per day) the average erythrocyte deformability index markedly increased. The blood viscosity remained unchanged. By increasing erythrocyte deformability, the blood flow rate improved. (70)
A study of 80 subjects divided into two control groups consisting of 20 healthy volunteers and 60 volunteers with poorly-controlled type-2 diabetes. Researchers examined the red blood cell membrane structure and shape changes of blood before and after treatments. (52% of the diabetic group were also taking anticoagulant medications. 67% of the diabetic group were taking anticholesterol medication. 73% of the diabetic group were also taking antihypertensive medications. 97% of the diabetic group were also taking hypoglycaemic medications. There were no interactions with the medications.) Results show taking Flavay® (daily doses of 200 mg) significantly improves the deformability and membrane protein structure of red blood cells in type-2 diabetics and positively contributes to red blood cell functioning. (182)
An in vitro study shows Flavay® increases red blood cell membrane fluidity, potentially owing to inducing modification of the lipid bilayer and lipid-protein interactions. This research shows Flavay® can significantly increase membrane fluidity especially at the membrane surface as compared with untreated red blood cells. Flavay® is shown to have protective effects against lipid peroxidation, generation of thiobarbituric acid reactive products and oxidative hemolysis. Flavay® reduces the lipid peroxidation and oxidative hemolysis either by reducing free radicals or by chelating metal ions, or by both. (183)
A double-blind, randomized, placebo-controlled intervention study with 28 male smokers with 200 mg per day of Flavay®. At baseline, after 4 and 8 weeks researchers measured macro- and microvascular function and a cluster of systemic biomarkers for major pathological processes occurring in the vasculature: disturbances in lipid metabolism and cellular redox balance, and activation of inflammatory cells.
In the Flavay® group, serum total cholesterol and LDL decreased significantly by 5% and 7%, respectively in volunteers with elevated baseline levels. Additionally, after 8 weeks the ratio of glutathione to glutathione disulphide in erythrocytes rose from baseline by 22% the Flavay® group. Researchers observed that Flavay® supplementation exerts anti-inflammatory effects in blood towards ex vivo added bacterial endotoxin and significantly reduces expression of inflammatory genes in leukocytes and noted a "significant improvement of overall vascular health" in the Flavay® group. (454)
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I can’t even tell you how much I appreciated finding your product Flavay and the incredible results and relief I have gotten from taking it... I skeptically ordered two bottles... And low and behold, it works. I read that I could take more than 2 that some people had to take 4 or 5 at a time, so I did, hoping and praying, and my prayers were answered. To say thank-you is an understatement, and I have been able to stop all other pain meds. I honestly was on a one way road to nowhere, now I am free again..a feeling I haven’t had in over 12 years. Thank-you!!!!!!!!!!!!!!! —Ms. Beth B.*
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I start feeling pain in my joints after a few days of not taking Flavay. —Mr. Mark H.*
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I love your product called Flavay. I feel it does the job! —Mr. R.H.*
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Since I started taking Flavay I felt so good and I'm hoping to keep getting better. I started taking Flavay for my knee but since I started taking Flavay I've cut way back on asthma meds. The medication affects my brain badly. I want to control asthma instead of it controlling me. Flavay is a big help, I am so happy! —Ms. J.I.*
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I just wanted to write and say WOW... I was so skeptical of your product at first and really had a negative attitude when I started taking it. I am a 40 yr old female with anxiety, mild ADHD and a host of arthritis and inflammation issues. It was a struggle for me to get out of bed everyday and focus on what needed to be done. I had no focus, no attention span, no energy, and no desire to do anything. About a week into taking Flavay and Flavay Plus, I started noticing that I could think a little clearer. My rheumatoid arthritis flare-ups weren't so bad, though I still have them. feeling better, and having more energy. I never thought I would feel like my old self again. I don't know exactly how you do it,...but this stuff works! I am telling all of my friends to try it because you've given me my old life back! Thank you! —Ms. L.A.*
I am not one to review products, but i can't deny some of the benefits i've experienced using both your biomor curcumin and flavay products. I've been taking both for a few months now, and the two major benefits i've noticed are 1) joint strength and mobility (for workouts) as i am lifting much heavier weights without injury 2) I am a paroxsymal Afib sufferer, and my episodes have gone from 2-3 per week down to zero (most weeks). This can't just be a coincidence. I think there is definitely something in your formulas that stop inflammation and get your body in balance and healing itself. —Mr. B.V.W.*
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