Many significant studies establish the efficacy of Flavay® in protecting retinal cells against oxidative damage, restoring retinal blood flow and in reducing ocular inflammation.
Flavay® is proven to reduce pressure in ophthalmic membranes by preventing abnormal leakage of fluids into the orbital cavity and tissues and thereby slow down progression of retinopathies. In various clinical trials, Flavay® showed significant improvement with various types of retinal degenerations, including macular degeneration, diabetic retinopathy, retinitis pigmentosa, and hemorrhagic and hypertensive retinopathy. (69-72)
In another study, the effects of Flavay® were measured on retinopathy subjects with microaneurysms, hemorrhages, exudations (oozing fluids) and neovascularization after capillary hypoxia. Retinal infectional lesions were stabilized in 80% of those taking Flavay®. (72)
An in vivo study demonstrated Flavay® protects the retina against hyperglycemic damage. Notably, the structure of the retina improved in the Flavay® diabetic group, as compared with non-treated diabetic group. (373)
The hallmark of optic neurodegenerative diseases (including retinopathy and glaucoma) is retinal ganglion cell-death. Studies show Flavay® protects oxidative stress-injured retinal ganglion cells by inhibiting apoptosis (death). (328,329)
Flavay® is found to protect the retina against hyperglycemic damage. Notably, the structure of the retina improved in the Flavay® diabetic group, as compared with non-treated diabetic group. (373)
An open study measured the effects of Flavay® on 26 subjects with retinopathy and capillary fragility, microaneurysms, exudates (oozing fluids) and hemorrhages. Capillary fragility (measured with Parrot's angiosterrometer) improved in 11 subjects, condition of the ocular fundus improved in 15 subjects, and overall improvement in 21 subjects was reported. (250)
In clinical trials, Flavay® is shown to reduce pressure in ophthalmic membranes by preventing abnormal leakage of fluids into the orbital cavity and tissues and thereby slow down progression of retinopathies. Flavay® seals leaky capillaries, strengthens vessels and prevents outflow of blood or liquid. The number of microbleedings in retinal tissue is thereby reduced and visual acuity can improve. (249,250)
A review of 26 clinical studies reveals Flavay® significantly improved vascular lesions, microaneurysms, and exudates associated with diabetic retinopathy. (71)
The effects of Flavay® (100 mg per day) were measured on 147 persons with retinopathy. Flavay® improved all cases of exudations linked to ischemia (inadequate blood supply) linked to a diabetic, ateriosclerotic, inflammatory, degenerative and myopic nature. (69)
The effects of Flavay® (150 mg per day) were measured on 30 retinopathy subjects who suffered from microaneurysms, hemorrhages, exudations and neovascularization after capillary hypoxia. Retinal infectional lesions were stabilized in 80% of those taking Flavay®. (72)
The health of our eyes depends to a great extent on the integrity of the fine vessels that supply blood to the area. Flavay® helps to both relieve and prevent vascular fragility as it strengthens vessels and helps to prevent the root causes of vessel occlusion—effectively reducing the risk of a rupture or hemorrhage. (23,35,36,77-79,87,146,267,268)
Flavay® reinforces collagen structures of the retina (which is 80% collagen). Flavay® is clinically proven to improve strength and tone of veins, arteries, capillaries (the smallest vessels) and lymphoid tissues and thereby improve circulation and microcirculation, and reduce leakage. (47,48,82,205)
Flavay® is shown to reduce swelling and reduce pressure in ophthalmic membranes in clinical trials. Here we highlight anti-inflammatory mechanisms. (249,250)
Flavay® controls release and synthesis of destructive enzymes that cause inflammation (simultaneously protecting hyaluronic acid, collagen and elastin). Studies show Flavay® reduces destructive ratios and concentrations of prostanoids, leukotrienes and thromboxanes thereby preventing release and synthesis of compounds that promote inflammation, such as histamine, serine proteases and prostaglandins. (18,25,53,61,74,81,185,230,265,274,292,296,302)
Flavay® reduces damaging effects of elastase, collagenase and hyaluronidase by altering membrane receptor conformation of vascular walls and preventing destructive enzymes from attaching to and degrading vascular walls. (23,67,268)
Flavay® further prevents destruction of vascular walls by preventing the attachment to membranes of histamine, which decreases strength of vessel walls. (35,56,77-79,87,146)
Research found Flavay® reduced damage to connective tissue in capillaries by up to 70%. (18,19,23,60,266-268,279)
Human studies also show taking Flavay® significantly increases serum total antioxidant activity in both lipid (fat) and aqueous (water) phases of oxidation. Flavay® boosts activity of vitamin A in eyes, increases intracellular antioxidant activities of vitamins C and E, catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPx), improving the body’s endogenous antioxidants. (33,83,274,369,371)
Patented as a strong antioxidant, Flavay® protects collagen, elastin and hyaluronic acid against over-crosslinking and inhibits destructive pro-inflammatory enzymes. (18,25,61,74,81,391,185,230,387,388)
Many research studies highlight the role of nitric oxide in a wide range of ocular diseases such as glaucoma, retinal degeneration and uveitis. (458)
Nitric oxide is an important regulator of homeostatic processes in the eye and changes in its synthesis leads to a variety of eye diseases. Both underproduction and overproduction of nitric oxide contribute to disease conditions in the eye. (375,458)
Flavay® is shown to balance nitric oxide activity, both to stimulate normal synthesis and inhibit over-production of nitric oxide. Studies show Flavay® protects against toxic overproduction of nitric oxide by blocking nitric oxide synthases (NOSs). (53,261,265,302,306,315,372,414)
Both over-expression and under-expression of nitric oxide contribute a variety of eye diseases such as glaucoma, retinal degeneration and uveitis. (458)
Flavay® works to both stimulate normal synthesis of nitric oxide and to inhibit overproduction of nitric oxide. (103)
In endothelial cells challenged with reactive nitrogen species, Flavay® protected against vitamin E depletion, potentially protecting vascular endothelium from oxidative stress from reactive nitrogen species such as nitric oxide. (261,301)
Study comparing activity and synthesis of superoxide dismutase (Cu/Zu-SOD) and nitric oxide in the diabetic and non-diabetic cerebellum and cerebral cortex shows: Diabetes significantly decreases synthesis and activity of Cu/Zu-SOD and Flavay® significantly increases synthesis of Cu/Zu-SOD. Diabetes reduces synthesis of nitric oxide and Flavay® elevates levels back to normal. (372)
Flavay® possesses endothelium-dependent-relaxing (EDR) activity in blood vessels by increasing nitric oxide production and stimulates vascular endothelial growth factor, a signaling factor involved in initiation of wound healing. (53,265,274)
Flavay® promotes nitric oxide production by vascular endothelium, inhibits the synthesis of thromboxane in platelets and leukotriene in neutrophils, modulates the synthesis and secretion of lipoproteins, arrests tumor growth, and inhibits carcinogenesis in different models. (10,265,302)
Nitric oxide stimulates collagen synthesis and subsequent healing at wound sites. (312,313)
In addition, the induction of vascular endothelial growth factor (VEGF) is a crucial step in the reepithelialization phase of skin repair. (314,315)
Flavay® is shown to stimulate the expression of VEGF in cultured keratinocytes, showing Flavay® supports wound healing. (316,317)
Experiments show Flavay® relaxes sympathomimetic-induced contractions in a concentration-dependent manner. Flavay® also increases nitric oxide (NO) levels, counteracting the vasoconstrictor effects of sympathomimetics. (10,265)
Oxygen and light generate free radicals or precursors, and oxidative damage to lens proteins leads to increasing opacity. Both animal and human studies show that oxidative stress plays a critical role in macular degeneration, glaucoma, retinal degeneration and retinopathies, and cataracts. (243,244,320-322,324-327)
Due to the exposure to light and high oxygen concentration, the oxidative stress burden is higher in the eye than other tissues, which can be further complicated by additional oxidative stressors such as smoke, smog, chemical pollution and chronic exposure to "blue light" digital-screen radiation. (243,324-327)
A recent Harvard Health Letter warns that chronic exposure to fluorescent and LED light ("blue light") may lead to macular degeneration, glaucoma, and retinal degenerative diseases which can eventually cause serious vision loss and blindness. (322)
Oxidative stress is a major cause of cell death and retinal ganglion apoptosis (cell death) is the key symptom of optic neurodegenerative diseases (including retinopathy and glaucoma). (243,244,320-327)
Studies show Flavay® protects oxidative stress-injured retinal ganglion cells by inhibiting apoptosis (cell death). (328,329)
"[A] method for preventing and fighting the harmful biological effects of free radicals in the organism of warm blooded animals and more especially human beings, namely cerebral involution, hypoxia following atherosclerosis, cardiac or cerebral infarction, tumour promotion, inflammation, ischemia, alterations of the synovial liquid, collagen degradation, among others."
—U.S. Patent No. 4,698,360 (1987).
What the brochure says it's true. I was having problems seeing at night and so I really didn't want to drive at night. Halogen headlights were a problem but now with Flavay I see things in the dark like a kid. —Mr. D.T.*
Flavay has really helped with my glaucoma. After a few weeks my doctor was surprised because my numbers went down. —Ms. Yvonne B.*
I’ve got three of us taking Flavay, all three of us got better from glaucoma. I’m 82 and a healthy man and I still act like one. I take two Flavay per day. —Mr. Harvey S.*
After 2-3 weeks of taking Flavay I can tell a distinct difference for my eyes. Now, my stainless steel refrigerator looks normal, I don't see irritating waves and or need to blink as before. It's such an easy way for me to gauge what Flavay is doing for my eyes. Also, I see less of a halo around light. I can tell a distinct difference. I'm delighted to see a difference in my skin, too. My aged skin looks a lot better. It's a quality difference in my skin. And I see a huge difference in my mother's skin, a softness that it didn't have before. —Ms. Jane F.*
I was skeptical but desperate when I first ordered Flavay for my diabetic retinopathy. In less than one month the Flavay has produced a dramatic improvement in my condition. My eyes clear as soon as I take my morning dose. I am a doctor of pharmacy and had never heard of your product but you bet I will spread the word... Thank you for saving my vision. The laser surgery just made it worse and my doctor had all but given up so I searched the web for a remedy and found your product. Flavay is remarkable! —Dr. H.H.*
After taking Flavay and Flavay Plus (about four months) my vision is more clear, so much so that I can drive a car and even read a newspaper. Macular degeneration may have etched areas of my retina and I still have to move my eyes around to find spots where I can see the best—but even that has improved a little. I can hardly believe my improvement. I’m astounded that something so simple, strengthening the capillaries in the eyes, has meant so much improvement. —retired medical doctor*
My mom says she feels better and so she stops taking Flavay and Flavay Plus, and then she notices her vision starts getting worse and her memory starts slipping, so she gets back on Flavay and Flavay Plus. She loves what they do for her. —Ms. X.Y.*
I have diabetic retinopathy and for about a year I was blind in one eye, but now I can see out of that eye. Not well enough to read, but improving, so I'll keep taking Flavay and Flavay Plus, currently taking 2 Flavay and 4 Flavay Plus. Did you know that these products are the only ones out there which help my condition, the only ones, and I'll keep taking them. —Mr. Mark M.*
I have been using your product (Flavay) for over a year now and I have found it quite useful for diabetic retinopathy. My right eye is almost blind and my left has very little vision. Even so your product has returned some vision to my eyes. —Dr. F.R.H.*
Flavay and Flavay Plus are helping my wife's eyes. She picked out a Cessna 350 in the sky lately. She hasn't been able to do that until now. —Mr. J. McDonald*
My friend and neighbor has been giving me Flavay bottles for some months because I would tell him when I was out of capsules. I've been using them. I have noticed improvements, especially with my vision. —Mr. R.F.*
I have tried everything else and your Flavay really helps my eyesight. I was having trouble seeing at night and now I don't have that problem anymore. I love Flavay. I also had a blown knee that they had wanted to do surgery on and now I don't have to. I love the Flavay, I really like it! —Ms. T.K.*
I have found Flavay to be a wonderful product. I buy it for my mum's eyes, but we also notice it improves her cognitive function. —Ms. N.S.*
I can read three lines up on the eye chart since taking Flavay and Flavay Plus for my retinopathy! (83-year-old customer whose eye-doctor's office called to receive a Flavay brochure. The doctor's nurse was laughing and saying, “Whatever your product is, it's good!”) —Ms. Daisy B.*
Flavay has so dramatically improved my vision that my son has arranged for me to have a new puppy! I'm a dog lover but when my dog died seven years ago I wouldn't have a new one because I couldn't see well enough to take care of it. —Ms. Daisy B.*
I purchased Flavay for my mother with advanced retinopathy. After taking Flavay her doctor was totally taken aback by what he found, her vision test had improved by 3 lines. We give thanks to the Lord for making this product available —Ms. Judy E.*